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. 2019 Nov 8;68(3):656–669. doi: 10.1002/glia.23748

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© 2019 The Authors. Glia published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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SUMO1 knockdown downregulates PI3K/AKT pathway. Immunocytochemistry images showing a decrease in the expression of (a) PI3K (red), (b) pAKT (red), (c) pCREB (red), and (d) BDNF (red) in SUMO1 knockdown cells compared to control. Nuclei are stained blue with DAPI, and microglia are stained green with Lectin. Scale bar = 10 μm. BDNF, brain‐derived neurotrophic factor; CREB, cAMP response element‐binding protein; PI3K, phosphatidylinositol 3‐kinase [Color figure can be viewed at http://wileyonlinelibrary.com]