Table 6.
Imaging diagnosis
|
Hepatocellular carcinoma n (%) |
Intrahepatic cholangiocarcinoma n (%) |
Combined hepatocellular cholangiocarcinoma n (%) |
|
|---|---|---|---|
| Maximum diameter of primary tumor | n = 18 524 | n = 901 | n = 142 |
| ≤1 cm | 995 (5.4) | 22 (2.4) | 1 (0.7) |
| >1 cm to ≤2 cm | 5367 (29.0) | 102 (11.3) | 13 (9.2) |
| >2 cm to ≤3 cm | 4354 (23.5) | 179 (19.9) | 27 (19.0) |
| >3 cm to ≤5 cm | 3733 (20.2) | 246 (27.3) | 41 (28.9) |
| >5 cm to ≤10 cm | 2841 (15.3) | 279 (31.0) | 42 (29.6) |
| >10 cm to ≤15 cm | 898 (4.8) | 60 (6.7) | 14 (9.9) |
| >15 cm to ≤20 cm | 232 (1.3) | 12 (1.3) | 4 (2.8) |
| >20 cm to ≤25 cm | 73 (0.4) | 1 (0.1) | 0 (0.0) |
| >25 cm | 31 (0.2) | 0 (0.0) | 0 (0.0) |
| No. tumors | n = 18 629 | n = 923 | n = 139 |
| 1 | 11 424 (61.3) | 690 (74.8) | 84 (60.4) |
| 2 | 3150 (16.9) | 69 (7.5) | 20 (14.4) |
| 3 | 1236 (6.6) | 27 (2.9) | 7 (5.0) |
| 4 | 524 (2.8) | 18 (2.0) | 3 (2.2) |
| 5 | 276 (1.5) | 4 (0.4) | 2 (1.4) |
| ≥6 | 2019 (10.8) | 115 (12.5) | 23 (16.5) |
| Multifocal disease | n = 14 184 | n = 669 | n = 121 |
| Single lobe | 10 222 (72.1) | 534 (79.8) | 89 (73.6) |
| Both lobes | 3962 (27.9) | 135 (20.2) | 32 (26.4) |
|
Hepatocellular carcinoma Morphological classification of primary tumor on imaging |
n = 17 276 | ||
| Nodular | 15 307 (88.6) | ||
| Massive | 1308 (7.6) | ||
| Diffuse | 599 (3.5) | ||
| Other | 62 (0.4) | ||
| Arterial phase enhancement | n = 17 642 | n = 823 | n = 135 |
| No | 1214 (6.9) | 440 (53.5) | 16 (11.9) |
| Yes | 16 428 (93.1) | 383 (46.5) | 119 (88.1) |
| Venous phase washout | n = 16 180 | n = 729 | n = 113 |
| No | 1489 (9.2) | 543 (74.5) | 26 (23.0) |
| Yes | 14 691 (90.8) | 186 (25.5) | 87 (77.0) |
| Internal component of tumor | n = 16 941 | n = 761 | n = 137 |
| Solid | 16 793 (99.1) | 738 (97.0) | 136 (99.3) |
| Cystic | 148 (0.9) | 23 (3.0) | 1 (0.7) |
| Portal vein invasion by imaging | n = 17 855 | n = 854 | n = 137 |
| Vp0 | 15 669 (87.8) | 580 (67.9) | 97 (70.8) |
| Vp1 | 579 (3.2) | 61 (7.1) | 10 (7.3) |
| Vp2 | 463 (2.6) | 78 (9.1) | 9 (6.6) |
| Vp3 | 616 (3.5) | 102 (11.9) | 15 (10.9) |
| Vp4 | 528 (3.0) | 33 (3.9) | 6 (4.4) |
| Hepatic vein invasion by imaging | n = 17 263 | n = 808 | n = 133 |
| Vv0 | 16 401 (95.0) | 683 (84.5) | 119 (89.5) |
| Vv1 | 305 (1.8) | 45 (5.6) | 6 (4.5) |
| Vv2 | 295 (1.7) | 60 (7.4) | 4 (3.0) |
| Vv3 | 262 (1.5) | 20 (2.5) | 4 (3.0) |
| Bile duct invasion by imaging | n = 17 039 | n = 801 | n = 133 |
| B0 | 16 569 (97.2) | 488 (60.9) | 113 (85.0) |
| B1 | 195 (1.1) | 76 (9.5) | 6 (4.5) |
| B2 | 121 (0.7) | 99 (12.4) | 6 (4.5) |
| B3 | 96 (0.6) | 91 (11.4) | 5 (3.8) |
| B4 | 58 (0.3) | 47 (5.9) | 3 (2.3) |
| Tumor rupture | n = 18 337 | n = 759 | n = 144 |
| No rupture | 17 853 (97.4) | 753 (99.2) | 144 (100.0) |
| Suspected rupture | 316 (1.7) | 3 (0.4) | 0 (0.0) |
| Rupture | 168 (0.9) | 3 (0.4) | 0 (0.0) |
| Extrahepatic spread | n = 1091 | n = 264 | n = 41 |
| Lung | 319 | 48 | 6 |
| Bone | 204 | 22 | 2 |
| Adrenal gland | 67 | 6 | 2 |
| Lymph node | 410 | 148 | 27 |
| Brain | 11 | 1 | 0 |
| Peritoneum | 44 | 21 | 3 |
| Other | 36 | 18 | 1 |
| Percentages not calculated as multiple sites were allowed | |||
| Esophageal/gastric varices | n = 4195 | n = 30 | n = 15 |
| ≤F1, RC (−) | 2428 (57.9) | 21 (70.0) | 9 (60.0) |
| ≥F2, RC (+) | 1503 (35.8) | 8 (26.7) | 5 (33.3) |
| Rupture | 264 (6.3) | 1 (3.3) | 1 (6.7) |
| TNM Stage by LCSGJ | n = 18 207 | n = 882 | n = 138 |
| Stage I | 4583 (25.2) | 78 (8.8) | 24 (17.4) |
| Stage II | 7280 (40.0) | 268 (30.4) | 36 (26.1) |
| Stage III | 4162 (22.9) | 206 (23.4) | 32 (23.2) |
| Stage IVA | 1504 (8.3) | 118 (13.4) | 21 (15.2) |
| Stage IVB | 678 (3.7) | 212 (24.0) | 25 (18.1) |
For all parameters, n is the total number of patients excluding those in the “unknown” category, and (%) is the percentage of n.
B0, absence of invasion of the bile ducts; B1, invasion of (or tumor thrombus in) the third order or more peripheral branches of the bile duct, but not of second order branches; B2, invasion of (or tumor thrombus in) the second order branches of the bile duct; B3, invasion of (or tumor thrombus in) the first order branches of the bile duct; B4, invasion of (or tumor thrombus in) the common hepatic duct.; F1, small varices; F2, moderate varices; RC, red color sign; Vp0, absence of invasion of (or tumor thrombus in) the portal vein; Vp1, invasion of (or tumor thrombus in) distal to the second order branches of the portal vein, but not of the second order branches; Vp2, invasion of (or tumor thrombus in) second order branches of the portal vein; Vp3, invasion of (or tumor thrombus in) first order branches of the portal vein; Vp4, invasion of (or tumor thrombus in) the main trunk of the portal vein and/or contra‐lateral portal vein branch to the primarily involved lobe; Vv0, absence of invasion of (or tumor thrombus in) the hepatic vein; Vv1, invasion of (or tumor thrombus in) peripheral branches of the hepatic vein; Vv2, invasion of (or tumor thrombus in) the right, middle, or left hepatic vein, the inferior right hepatic vein, or the short hepatic vein; Vv3, invasion of (or tumor thrombus in) the inferior vena cava.