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. 2019 Dec 3;40(2):393–404. doi: 10.1111/liv.14304

Table 2.

Cox regression analyses on the influence of the 17β‐hydroxysteroid dehydrogenase 13 (HSD17B13) rs72613567 T > TA variant on A liver transplantation or death and B liver transplantation or liver‐related death. Competing risk regression analyses on the influence of the TA allele on C mortality, D liver‐related death and E (further) hepatic decompensation in the overall cohort

Patient characteristics

A

Liver transplantation or deatha

B

Liver transplantation or liver‐related deathb

C

Mortalitya

D

Liver‐related deathb

E

(Further) hepatic decompensationb

aHR 95% CI P value aHR 95% CI P value aSHR 95% CI P value aSHR 95% CI P value aSHR 95% CI P value
Age, per 10 y 1.28 1.09‐1.51 .003 1.24 1.05‐1.46 .013 1.41 1.15‐1.73 .001 1.31 1.07‐1.6 .01 1.18 1.02‐1.37 .027
HVPG, per mmHg 1.06 1.03‐1.09 <.001 1.06 1.03‐1.12 <.001 1.05 1.01‐1.09 .009 1.05 1.01‐1.09 .012 1.09 1.05‐1.12 <.001
MELD, per point 1.08 1.03‐1.12 <.001 1.07 1.03‐1.12 .001 1.04 0.98‐1.1 .21 1.02 0.96‐1.09 .44 1.05 1.0‐1.09 .034
T/TA or TA/TA, vs T/T (reference) 1.29 0.912‐1.82 .152 1.32 0.93‐1.88 .12 1.3 0.89‐1.91 .18 1.34 0.90‐1.98 .150 1.29 0.95‐1.77 .11

Abbreviations: 95% CI, 95% confidence interval; aHR, hazard ratio; aSHR, adjusted subdistribution hazard ratio; HVPG, hepatic venous pressure gradient; MELD, model for end‐stage liver disease.

a

Considering liver transplantation as a competing risk.

b

Considering liver transplantation and non‐liver‐related death as competing risks.