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. Author manuscript; available in PMC: 2020 Sep 12.
Published in final edited form as: J Med Chem. 2019 Aug 20;62(17):8357–8363. doi: 10.1021/acs.jmedchem.9b00340

Figure 4.

Figure 4.

Dose response of NT peptide in the presence of 18 (SBI-553) in the β-Arrestin (A) and Ca2+ flux (B) assays. Data were plotted and analyzed using GraphPad Prism V.7 and are presented as an average ± SEM (n=4). The compound shows divergent behavior, with no effect on the EC50 in the β-Arrestin assay but a strong rightward shift in the Ca2+ flux assay.