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Selected mouse or rat PK parameters for compounds 18 and 21e
| Compd sa |
Species | Clpb (mL/min/kg) |
Vdb (L/kg) |
Cmaxc (ng/mL) |
AUCc (ng.hr/mL) |
t1/2c (hr) |
%F | Brain:Plasma @1 hrc |
|---|---|---|---|---|---|---|---|---|
| 18 (SBI-553) | Mouse | 44.8 | 6.16 | 1460 | 4824 | 5.28 | 45 | 0.54 |
| 21e | Mouse | 79.4 | 7.68 | 627 | 3324 | 2.90 | 52 | 0.35 |
| 18 (SBI-553) | Rat | 81.0 | 7.02 | 3482 | 2693 | 2.23 | 48 | 0.98 |
Compounds dosed 5 mpk iv and 30 mpk po,
iv,
po
