Table 3.
Outcome data on long‐term follow up
| Number of surviving children assessed in follow up | Age at assessment | Definition of NDI | Neurodevelopmental test used | Proportion of children with NDI | |
|---|---|---|---|---|---|
| Aoki et al14 | 12/14 = 85.7% | Not described | “Handicapped” (not further explained) | Not described |
3/12 = 25.0% of surviving children 3/17 = 17.6% of all pregnancies |
| Fujisaki et al24 | 11/11 = 100% | 18 mo | “Mental retardation” was defined as developmental quotient of <70 | Kyoto Scale of psychological Development 2001 |
3/11 = 27.3% of surviving children 3/14 = 21.4% of all pregnancies |
| Hasegawa et al25 | 23/23 = 100% | 2 y (corrected) | Neurological complications were defined as cerebral palsy or mental retardation diagnosed by independent pediatric neurologists at corrected age of 2 y | Not described |
5/23 = 21.7% of surviving children (1 cerebral palsy, 4 mental retardation) 5/26 = 19.2% of all pregnancies |
| Lees et al20 | 443/461 = 88% | 2 y, corrected for prematurity | A cognitive Bayley III score or corrected Bayley II mental development index score of less than 85 or an estimated cognitive delay of more than 3 mo, cerebral palsy, with a GMFCS of more than 1, hearing loss needing hearing aids, or severe visual loss (legally certifiable as blind or partially sighted) | Bayley III Scales of Infant and Toddler Development or corrected Bayley II |
39/402 = 9.7% of surviving children (443 with known outcome, but 402 neurodevelopmental assessed) 39/502 = 7.8% of all pregnancies Cerebral palsy 6/402 = 1.5% of surviving children Cerebral palsy 6/502 = 1.2% of all pregnancies |
| Petersen et al30 | 5/5 = 100% | 2 y of age (corrected) | Developmental delay was defined as >1 SD below the mean | Griffiths Mental Developmental Scales |
1/5 = 20.0% of surviving children 1/36 = 2.8% of all pregnancies |
| Simonazzi et al13 | 12/12 = 100% | Median 30 mo (24‐58 mo) | Not described | Not described |
0/12 = 0% Cerebral palsy 1/12 = 8.3% of surviving children Cerebral palsy 1/16 = 6.3% of all pregnancies |
| Takahashi et al34 | 11/11 = 100% | Between 2 and 13 y median 6 y | Developmental quotient <70 | Kyoto scale of development and the Wechsler Intelligence Scale for Children III |
0/11 = 0% Cerebral palsy 1/11 = 9.1% of surviving children Cerebral palsy 1/18 = 5.6% of all pregnancies |
Abbreviations: GMFCS, gross motor function classification system; NDI, neurodevelopmental impairment; SD, standard deviation.