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. 2019 Nov 19;98(1):54–66. doi: 10.1111/imcb.12297

Figure 3.

Figure 3

NLRP3 inhibitor treatment alleviates thioacetamide (TAA)‐induced acute liver injury in hyperglycemic mice. (a–c) Serum alanine aminotransferase (sALT), aspartate aminotransferase (sAST) levels (n = 6 mice/group) and liver histopathology (representative of six experiments) were used to evaluate liver injury in diabetic mice and controls after treatment with CY‐09 and TAA. (d) Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining of liver sections (200× magnification, representative of six experiments). (e) The ratio of TUNEL‐positive cells in different experimental groups (n = 6 mice/group). (f) The levels of Bcl‐2, Bcl‐xL and β‐actin proteins were measured by western blot (representative of three experiments). *P < 0.05. CON, control; DAPI, 4′,6‐diamidino‐2‐phenylindole; HPF, high‐power field; NLRP3, NOD‐like receptor family pyrin domain‐containing 3 protein; STZ, streptozotocin.