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. 2019 Nov 19;98(1):54–66. doi: 10.1111/imcb.12297

Figure 5.

Figure 5

Mammalian target of rapamycin (mTOR) knockdown in Kupffer cells (KCs) alleviates thioacetamide (TAA)‐induced acute liver injury. (a–c) Serum alanine aminotransferase (sALT), aspartate aminotransferase (sAST) levels (n = 6 mice/group) and liver histopathology (representative of six experiments) were used to evaluate liver injury in diabetic mice and controls after treatment with mTOR‐siRNA and TAA. (d) Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining of liver sections (200× magnification, representative of six experiments). (e) The ratio of TUNEL‐positive cells in different experimental groups (n = 6 mice/group). (f) The levels of Bcl‐2, Bcl‐xL and β‐actin proteins were measured by western blot (representative of three experiments). *P < 0.05. HPF, high‐power field; sALT, serum alanine aminotransferase; sAST, aspartate aminotransferase; siRNA, small interfering RNA; STZ, streptozotocin.