Scheme 6.
Reagents & conditions: (a) NBS, AIBN, CHCl3, reflux, 4 h; (b) K2CO3, DMF, reflux, 12 h; (c) H2, Pd(C), MeOH, rt, 12 h; (d) 4‐tert‐butylbenzoyl chloride (29), pyridine, DMF, CHCl3, reflux, 6 h; (e) LiOH, MeOH/H2O, rt, 16 h.
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