Figure 3.

GC epithelial/tumorigenic module, M28, is upregulated in primary GC. (a) Correlation between M28 eigen‐gene and TCGA‐GCC stromal score inferred by ESTIMATE algorithm. The x‐ and y‐ axes are the first and second PC of M28, respectively. (b) ESTIMATE inferred stromal score distributions by NEB mutation status, in TCGA‐GCC (left) and vTCGA‐GCC (right). (c) Enrichment of oncogenic KIT/PDGFRA mutation signatures from gastrointestinal stromal tumors (GISTs) in stromal score correlated gene signature in TCGA‐GCC. (d) A GC tumorigenesis pathway captured by M28, interacts with GC stromal cells via NEB to promote epithelial‐mesenchymal transition (EMT) in GC. [Color figure can be viewed at http://wileyonlinelibrary.com]