1. Characteristics of participants in included studies.
|
Included participants (n) |
Lost to follow‐up (%) |
Age (years) |
Sex (% male) |
FEV1 (L or %) |
||||||
| Intervention | Control | Intervention | Control | Intervention | Control | Intervention | Control | Intervention | Control | |
| Comparison with usual care | ||||||||||
| Akinci 2011 | 27 | 25 | 41 | 36 | 71.8 (7.8) | 65.1 (10.2) | n.a. | n.a | 0.9 (0.3) | 1.0 (0.4) |
| Bösch 2007 | 38 | 12 | 21 | 8 | 63.8 (8.4) | 64.6 (6.8) | 52 (total group) | n.a. | 1.3 (0.5) | 1.4 (0.5) |
| Bourbeau 2003 | 96 | 95 | 10 | 17 | 69.4 (6.5) | 69.6 (7.4) | 52 | 59 | 1.0 (0.3) | 1.0 (0.3) |
| Casas 2006 | 65 | 90 | 26 | 20 | 70 (9) | 72 (9) | 77 | 88 | 43 (20) | 41 (15) |
| Chavannes 2009 | 79 | 73 | 14 | 18 | 64 (11) | 63 (11) | 59 | 67 | 62 (19) | 66 (16) |
| Chuang 2011 | 141 | 141 | n.a. | n.a. | n.a. | n.a. | 35 | 35 | n.a. | n.a. |
| Coultas 2005a | 72 | ‐ | 29 | ‐ | 68.3 (6.6) | ‐ | 43 | 46.2 (17.9) | ‐ | |
| Coultas 2005b | 72 | 73 | 32 | 30 | 70.1 (7.0) | 68.8 (10.4) | 33 | 54 | 42.2 (16.2) | 46.2 (17.2) |
| Emery 1998 | 25 | 25 | 8 | 0 | 67.4 (5.9) | 67.4 (7.1) | 40 | 48 | 1.1 (0.5) | 1.0 (0.4) |
| Faulkner 2010 | 10 | 10 | 40 | 20 | 70.8 (10.5) | 71.3 (4.5) | 90 | 70 | 2.0 (0.4) | 1.7 (0.5) |
| Gallefoss 1999 | 31 | 31 | 16 | 13 | 57 (9) | 58 (10) | 48 | 52 | 1.8 (0.5) | 1.7 (0.5) |
| Ghanem 2010 | 25 | 14 | 0 | 0 | 57 (11.6) | 56.4 (9) | n.a. | n.a. | 0.8 (0.4) | 0.6 (0.2) |
| Hill 2010 | 55 | 45 | 9 | 4 | 63.4 (9.6) | 65.7 (9.9) | 44 | 46 | 60.0 (14.3) | 58.2 (14.4) |
| Khdour 2009 | 86 | 87 | 17 | 17 | 65.6 (10.1) | 67.3 (9.2) | 44 | 44 | 1.0 (0.5) | 1.1 (0.5) |
| Kheirabadi 2008 | 21 | 21 | n.a. | n.a. | 56.6 (5.7) | 56.2 (4.1) | 62 | 76 | n.a. | n.a. |
| Koff 2009 | 20 | 20 | 5 | 5 | 66.6 (9.1) | 65.0 (8.2) | 45 | 50 | 33.6 (9.1) | 31.1 (10.2) |
| Monninkhof 2003 | 127 | 121 | 4 | 6 | 65 (7) | 65 (7) | 85 | 84 | 1.7 (0.6) | 1.8 (0.5) |
| Moullec 2008 | 14 | 26 | 21 | 38 | 62.9 (7.4) | 59.7(9.6) | 71 | 81 | 49.3 (14.9) | 46.8 (18.2) |
| Ninot 2011 | 23 | 22 | 13 | 18 | 65 (59‐74) | 61 (56 to 65) | 78 | 64 | 1.69 (1.17 to 2.01) | 1.52 (1.06 to 1.85) |
| Osterlund Efraimsson 2006 | 26 | 26 | 0 | 0 | 66 (9.4) | 67 (10.4) | 50 | 50 | n.a. | n.a. |
| Rea 2004 | 83 | 52 | 14 | 12 | 68 (44 to 48) (total group) | n.a. | 42 (total group) | n.a. | 1.2 (0.5) | 1.1 (0.5) |
| Rice 2010 | 372 | 371 | 10 | 13 | 69.1 (9.4) | 70.7 (9.7) | 98 | 98 | 1.1 (0.5) | 1.2 (0.5) |
| van Wetering 2009 | 102 | 97 | 25 | 17 | 65.9 (8.8) | 67.2 (8.9) | 71 | 71 | 58 (17) | 60 (15) |
| Wakabayashi 2011 | 52 | 50 | 19 | 14 | 72.9 (6.4) | 70.4 (8.6) | 88 | 84 | 1.5 (0.5) | 1.6 (0.7) |
| Head‐to‐head trials | ||||||||||
| Effing 2009 | 80 | 79 | 16 | 9 | 63.1 (7.9) | 63.7 (8.0) | 57 | 61 | 1.4 (0.6) | 1.4 (0.5) |
| Effing 2011 | 80 | 79 | 8 | 14 | 62.9 (8.1) | 63.9 (7.8) | 58 | 58 | 1.4 (0.5) | 1.4 (0.5) |
| Kara 2004 | 30 | 30 | n.a | n.a. | 61.1 (11.3) | 61.4 (11.1) | 78 (total group) | n.a. | n.a. | n.a. |
| Nguyen 2008 | 26 | 24 | 27 | 17 | 68.0 (8.3) | 70.9 (8.6) | 61 | 55 | 49.0 (16.8) | 50.3 (17.6) |
| Nguyen 2009 | 9 | 8 | 0 | 0 | 72 (9) | 64 (12) | 33 | 37 | 46.7 (18.7) | 34.4 (15) |
| Sassi‐Dambron 1995 | 47 | 51 | 13 | 24 | 67.5 (8.0) | 67.3 (8.0) | 55 | 45 | 1.1 (0.5) | 1.2 (0.6) |
| Stulbarg 2002 | 40; 37 | 38 | 10; 11 | 11 | 66.2 (6.4); 67.2 (7.6) | 65.7 (6.8) | 50/38 | 32 | 1.1 (0.4); 1.2 (0.3) | 1.0 (0.3) |