Comparison 3. Any HRT versus placebo: vasomotor outcomes at 3 months.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Hot flush frequency/week	8	1036	Mean Difference (IV, Random, 95% CI)	‐19.38 [‐27.50, ‐11.25]
2 Hot flush frequency ‐ log transformed	8	1036	Mean Difference (IV, Random, 95% CI)	‐1.20 [‐1.63, ‐0.77]
3 HFWWS	2	432	Mean Difference (IV, Random, 95% CI)	‐48.14 [‐64.22, ‐32.07]
4 HFWWS ‐ log transformed	2	432	Mean Difference (IV, Random, 95% CI)	‐1.55 [‐2.92, ‐0.19]
5 Hot flush severity (0‐3 scale, continuous) ‐ WMD	4	237	Mean Difference (IV, Random, 95% CI)	‐0.67 [‐1.09, ‐0.26]
6 Hot flush severity (dichotomous)	6		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
6.1 Presence versus absence of hot flushes	5	272	Odds Ratio (M‐H, Random, 95% CI)	0.11 [0.05, 0.24]
6.2 Moderate‐severe versus mild‐absent hot flushes	3	254	Odds Ratio (M‐H, Random, 95% CI)	0.17 [0.05, 0.65]
7 Hot flush severity (proportional odds ratios)	8	554	odds ratios (Random, 95% CI)	0.09 [0.05, 0.17]