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. Author manuscript; available in PMC: 2021 Jan 31.
Published in final edited form as: Circ Res. 2019 Dec 5;126(3):350–360. doi: 10.1161/CIRCRESAHA.119.315179

Table 1.

Top 10 Gene Ontology biological processes enriched with AF-related genes identified by the multi-omics integration analysis.

Gene set Description Total genes Observed genes P value FDR
GO:0060537 Muscle tissue development 371 94 3.0×10−17 5.7×10−14
GO:0014706 Striated muscle tissue development 357 92 3.7×10−17 7.1×10−14
GO:0048738 Cardiac muscle tissue development 200 63 9.0×10−17 1.7×10−13
GO:0010628 Positive regulation of gene expression 1911 302 2.2×10−16 5.0×10−13
GO:0071495 Cellular response to endogenous stimulus 1347 226 4.9×10−15 8.9×10−12
GO:0009719 Response to endogenous stimulus 1595 257 7.1×10−15 1.1×10−11
GO:0045893 Positive regulation of transcription, DNA-templated 1499 244 1.2×10−14 1.6×10−11
GO:0051240 Positive regulation of multicellular organismal process 1661 261 8.6×10−14 9.8×10−11
GO:0061061 Muscle structure development 610 122 1.2×10−13 1.3×10−10
GO:1903508 Positive regulation of nucleic acid-templated transcription 1583 250 1.8×10−13 1.5×10−10