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. 2020 Jan 27;18(1):e3000612. doi: 10.1371/journal.pbio.3000612

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© 2020 Roemhild et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — Three single-step mutants with resistance against 3 diverse antibiotics (upward bars) show CS to NIT (downward bars). Fold change of the MIC compared to susceptible wild-type strains. Light shading denotes an inoculum of 10⁶ cells; the overlaid dark shading corresponds to a larger inoculum of 10⁸ cells. Numerical data are available in S1 Data. CS, collateral sensitivity; MEC, mecillinam; MIC, minimum inhibitory concentration; NIT, nitrofurantoin; PRO, protamine sulfate; TGC, tigecycline.