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. 2020 Jan 27;16(1):e1008347. doi: 10.1371/journal.pgen.1008347

Fig 3. Telomere labeling shows inaccurate sizing of telomere-adjacent gap segments in HG38 subtelomere regions.

Fig 3

Blue bars represent the nick sites in hg38 reference. Yellow bars with green Nt.BsPQ1 nick sites represent the main haplotype seen in the genomes. A black dashed arrow indicated the width of the telomere-adjacent gap sequence that should be deleted from the hg38 reference. An image below the haplotype shows a single telomere labeled molecule confirming the end of the chromosome arm. These telomeres were labeled using CRISPR-Cas9 to tag the telomere repeat and incorporate a fluorophore[32]. None of the subtelomeric haplotypes for each of these arms extends past the telomere label shown here.