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. 2020 Feb 7;69(5):136–139. doi: 10.15585/mmwr.mm6905a5

TABLE. Recommended minimum ages for administration of DTaP-IPV-Hib-HepB vaccine and intervals between doses — United States, 2020*.

Parameter Age/Interval
Minimum age for any dose 6 weeks
Minimum interval between doses 1 and 2 4 weeks
Minimum age for dose 2 10 weeks
Minimum interval between doses 2 and 3 4 weeks
Minimum age for dose 3 24 weeks
Maximum age for any dose 4 years, 364 days (do not administer on or after the fifth birthday)

Abbreviations: DTaP = diphtheria and tetanus toxoids and acellular pertussis; Hib = Haemophilus influenzae type b; HepB = hepatitis B; IPV = inactivated poliovirus.

* The DTaP-IPV-Hib-HepB vaccine (Vaxelis; MCM Vaccine Company) was licensed in December 2018 and will not be commercially available in the United States before 2021.

If the third dose of DTaP-IPV-Hib-HepB is given before age 24 weeks, an additional dose of hepatitis B vaccine should be given at age ≥24 weeks to complete the hepatitis B series.