1. Change in the size of the wheal obtained through the prick test.

Study ID	Result
Fernandez‐Rivas 2009	After 6 months the patients in the active group had a significant decrease in skin prick test (SPT) to the Pru p 3 (peach extract). The cutaneous tolerance index (CTI) was 1.83 (95% CI: 1.16–2.87, P < 0.05), meaning that after 6 months of SLIT, a concentration of peach extract 1.83 times higher was needed to induce the same wheal area as in T0. Patients in the placebo group did not show changes in the SPT response (CTI 0.87, 95% CI: 0.48–1.55, P > 0.05).
Kopac 2012	Wheal size at IDT with different amounts of rMal d 1 at T0 and T8 reported as Δ T0‐T8 did not reveal a statistical significance in active vs control group (Mann‐Whitney‐U‐Test).