2. Change in the level of sIgE.

Study ID	Result
Fernandez‐Rivas 2009	sIgE to rPru p 3 showed a significant increase both in the active [T0: 3.08 (1.73–5.48), T1: 4.94 (2.63–9.28), and T6: 4.23 (2.17–8.23; P < 0.001] and placebo [T0: 3.42 (1.55–7.57), T1: 4.78 (2.00–11.4), and T6: 4.04 (1.61–10.13) ; P = 0.025] groups, although the increase remained only significant at T6 in the former (active 4.23, P < 0.001; placebo 4.04, P = 0.079, T‐test). However, no significant inter‐group differences were observed (P = 0.456). None of the patients with negative IgE to rPru p 3 at T0 converted to positive at T1 or T6.
Kopac 2012	There was no significant change in Δ T0‐T8 in sIgE level to Mal d 1 in active vs control group [active 5.12 (3.5–25.2), control 3.50 (1.6–21.7), P= 0.52, Mann‐Whitney‐U‐Test].