3. Change in the level of specific serum IgG4.

Study ID	Result
Fernandez‐Rivas 2009	IgG4 to nPru p 3 showed a different evolution between groups (P = 0.022) with a significant increase in the active arm [T0: 0.11 (0.06–0.18), T1: 0.12 (0.07–0.20), and T6: 0.13 (0.07–0.24); P = 0.007] not observed in the placebo one [T0: 0.10 (0.05–0.22), T1: 0.10 (0.05–0.21), and T6: 0.09 (0.04–0.18); P = 0.185].
Kopac 2012	There was no significant change in Δ T0‐T8 in IgG4 level to Mal d 1 in active vs control group [active 0.11 (0.02–0.31), control 0.04 (0.00–0.22), P= 0.06, Mann‐Whitney‐U‐Test].