Study	Reason for exclusion
Akdis 2011	1. Invited speaker presentation, not original contribution (not RCT).
Asero 1998	1. Observational study (not RCT) and authors used SCIT.
Asero 2007	1. Systematic review, not RCT.
Bolhaar 2005	1. Paper is case report (not RCT).
Boyano‐Martínez 2013	1. Cross‐sectional study.
Conference Review 2009	1. Congress report.
Conference Review 2013	1. Congress report.
Cromwell 2011	1. Narrative review, not original contribution.
Hansen 2004	1. Authors used SLIT and SCIT with birch pollen extract, not fruit extract.
Kinaciyan 2007	1. Not RCT. 2. Authors used SLIT with birch pollen extract.
Lamotte 2013	1. Systematic review, not RCT.
Nurmatov 2013	1. Systematic review, not RCT. 2. Focus is peanut immunotherapy.
Nurmatov 2014	1. Systematic review, not RCT.
Pereira 2009	1. Case report study (not RCT). 2. Did not evaluate an immunotherapy intervention.
Schnoor 2011	1. Not RCT.
Wisniewski 2012	1. Narrative review, not original contribution.