. Author manuscript; available in PMC: 2020 Dec 1.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2019 Oct 4;46(6):565–576. doi: 10.1007/s10928-019-09657-0

Table 2.

Parameter estimates for the selected PK model

Parameter	Definition	Estimate (RSE)	SIR median (95% CI)
CL/F^*	Oral clearance (L/hr)	52.7 (8)	52.4 (42.7 – 62.2)
V/F^*	Volume of distribution (L)	1780 (18)	1883 (1261 – 2361)
ART_CL	Fraction change in CL for ART patients	0.948 (26)	1.02 (0.48 – 1.65)
K_a	Absorption rate constant (hr⁻¹)	0.101 (31)	0.110 (0.05 – 0.19)
BSV_CL	Between subjective variability in CL/F (%CV)	70.3 (10)	70.5 (58.9 – 91.4)
BSV_V	Between subjective variability in V/F (%CV)	60.4 (21)	63.2 (35.3 – 94.0)
RUV₁	Additive residual variability (SD)	44.3 (53)	44.6 (30.5 – 60.5)
RUV₂	Proportional residual variability (%CV)	10.2 (29)	10.3 (6.3 – 15.9)

Parameters are allometrically scaled to a 70-kg person, RSE is relative standard of error, SIR is sampling importance resampling.