. Author manuscript; available in PMC: 2020 Dec 1.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2019 Oct 4;46(6):565–576. doi: 10.1007/s10928-019-09657-0

Table 4.

Parameter estimates for the selected survival model

Parameter	Definition	Estimate (RSE)	SIR median (95% CI)
λ_o	Baseline hazard	0.0367 (17)	0.0365 (0.0241 – 0.0473)
β_o	Shape parameter of the hazard function	2.32 (16)	2.30 (1.61 – 3.25)
SEX_male	Effect of being male on the baseline hazard	−1.38 (29)	−1.38 (−2.20 – −0.695)
DOSE_100/400	Effect of receiving 100 or 400 mg of sertraline daily on the baseline hazard	1.07 (38)	1.03 (0.25 – 1.82)

RSE is relative standard of error and SIR is sampling importance resampling.