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. 2020 Jan 30;126(3):395–412. doi: 10.1161/CIRCRESAHA.119.315891

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© 2020 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 1. — Pathways involved in cardiac cellular calcium cycling. The schematic shows part of a ventricular myocyte including transverse (T) tubules. From left to right, the sarcolemma contains sodium-calcium exchange (NCX); L-type Ca channel (LTCC); transient receptor potential (TRP) channels; connexin hemichannels; Na-K pump; Na channel; PMCA (plasma membrane Ca-ATPase); Orai. The sarcoplasmic reticulum (SR) contains ryanodine receptor (RyR); SR Ca-ATPase (SERCA) and its regulatory protein, PLN (phospholamban); STIM1 (stromal interaction molecule 1).