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Inflammasome activation driven by GBPs.
GBPs can mediate inflammasome activation by lysing the vacuole of pathogens and/or direct lysing cytosolic bacteria leading to the exposure of PAMPS such as LPS and DNA which can activate Casp11 and AIM2, respectively. Certain GBPs can also tetramerize and bind to Casp11 or Nlrp3 thereby lowering the threshold for their activation. For more details see main text.
