Table 1.

Summary of IRG/GBP mediated control of Toxoplasma in different murine and human cell lines. For references see main text.

	Mouse (MEF, macrophages, astrocytes)			Human epithelial A549	Human HAP1 (haploid fibroblastlike leukemia cell)
	IRGs	GBPs	Toxoplasma virulence factors	GBPs	GBPs
Recruited to the PV or Toxoplasma	Irgm2, Irgm3, Irga6, Irgb6, Irgd recruited to the PV	•Gbp1, 2, 3, 5, 7 recruited to PV •Gbp2 recruited to Toxoplasma	Combating GTPase recruitment: ROP18 (type I/II) ROP5 (type I/III)	GBP1 not recruited to PV	GBP1–5 recruited to 8% PVs
Ability to control Toxoplasma	Irgm1, Irgm3, Irga6, Irgd able to control Toxoplasma replication	•Gbps on chromosome 3 in bulk (1, 2, 3, 5, 7) control Toxoplasma replication •Gbp1 controls Toxoplasma replication	ROP16 (type I/III) ROP17 GRA7	GBP1 controls on of type II, but not type I	GBP1–5 do not control replication of type II
			Enhancing GTPase recruitment: GRA15 (type II)