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Pharmacodynamic analysis of vorinostat through protein expression of acetylated histone H3 and pro‐apoptotic BIMEL in PBMC. PBMC were harvested at baseline (Pre) and 4 h after dose (Post) of gefitinib and 200 mg (A: n = 3), 300 mg (B: n = 3), and 400 mg (C: n = 5) vorinostat on day 2 of cycle 1. Protein expression in PBMC was determined by western blotting
