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Off–target gene mutations identified in patients during treatments with gilteritinib and crenolanib
| Gilteritinib | Crenolanib | |
|---|---|---|
| RAS/MAPK pathway genes |
NRAS, KRAS, PTPN11 CBL, BRAF |
NRAS, KRAS, PTPN11 |
| Epigenetic‐modifying genes | IDH2 |
IDH1, IDH2 TET2, DNMT3A ASXL1, BCOR |
| Myeloid transcription factor genes |
CEBPA RUNX1 |
CEBPA RUNX1 |
| Spliceosome‐complex genes |
U2AF1 SF3B1 |
|
| Cohesion complex genes | STAG2 | |
| Others |
WT1 TBL1XR1 BCR‐ABL |
