Figure 4.

Survival analyses showing prognostic significance of UCHL1 expression in high‐grade neuroendocrine lung cancer (HGNEC) patients and the prognostic difference according to histology. The receiver operating characteristics curves for recurrence provided an immunohistochemical staining score of 70 as an adequate cut‐off value of UCHL1 levels. The prognostic value of a high UCHL1 level (≥70) in HGNEC patients was statistically significant for disease‐free survival (DFS, A; P = 0.005), and marginally significant for overall survival (OS, B; P = 0.081). There was no statistically significant difference between large cell neuroendocrine cancer and small cell lung cancer for DFS (C; P = 0.309) and there was a marginally significant difference for OS (P = 0.089)