Table 3.
Factors associated with high‐UCHL1 expression in patients with resected HGNEC
| Variable |
High UCHL1 level (≥70) |
Low UCHL1 level (<70) |
P‐value |
|---|---|---|---|
| Age, y (mean ± SD) | 70 ± 9 | 69 ± 9 | 0.777 |
| Sex | |||
| Men | 37 | 21 | |
| Women | 8 | 6 | 0.645 |
| Brinkman index (mean ± SD) | 1060 ± 561 | 1000 ± 477 | 0.641 |
| FEV1.0% (mean ± SD) | 65.1 ± 9.6 | 70.4 ± 11.0 | 0.040 |
| Tumor size, cm (mean ± SD) | 3.3 ± 2.2 | 3.7 ± 1.8 | 0.410 |
| Lymph‐vascular invasion | |||
| Positive | 43 | 25 | |
| Negative | 2 | 2 | 0.595 |
| Lymph node metastasis | |||
| Positive | 17 | 9 | |
| Negative | 28 | 18 | 0.704 |
| Histology | |||
| SCLC | 27 | 7 | |
| LCNEC | 18 | 20 | 0.005 |
| pTNM stage | |||
| I | 24 | 13 | |
| II‐IV | 21 | 14 | 0.670 |
| Synaptophysin | |||
| Positive | 35 | 17 | |
| Negative | 10 | 10 | 0.174 |
| CD56 | |||
| Positive | 45 | 27 | Not evaluable |
| Negative | 0 | 0 | |
| Chromogranin A | |||
| Positive | 35 | 13 | |
| Negative | 10 | 14 | 0.010 |
Abbreviations: FEV1.0, forced expiratory volume in 1 s; HGNEC, high‐grade neuroendocrine carcinoma; LCNEC, large cell neuroendocrine carcinoma; SCLC, small cell lung cancer; TNM, pathological tumor, node and metastasis.
The bold values are statistically significant with P‐value < 0.05.