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. 2020 Jan 15;111(2):667–678. doi: 10.1111/cas.14278

Figure 2.

Figure 2

Genetic features of 9 NRF2‐high NSCLC cell lines without mutations in the CUL3‐KEAP1‐NRF2 pathway. A, Summary of SNP detected in the KEAP1, NRF2 (NFE2L2) and CUL3 genes. In Figure 1B, 9 cell lines were identified as NRF2‐high cell lines without non–synonymous mutations in the KEAP1, NRF2 (NFE2L2) and CUL3 genes: NCI‐H2122, RERF‐LC‐MS, NCI‐H1623, NCI‐H1435, SKM‐ES‐1, MOR‐CPR, NCI‐H1437, NCI‐H2087 and NCI‐H2030. Non–exonic SNPs detected in these 9 cell lines are summarized in the bottom row. B‐D, Non–exonic SNP detected in only the 9 NRF2‐high NSCLC cell lines in the KEAP1 (B), NRF2 (C) and CUL3 (D) loci. SNP localized in extended promoter regions, which included 1000 bases upstream of the TSS, were marked with filled diamonds (♦). SNP localized in cis‐regulatory regions, which were defined by DNase‐seq (Z score > 1.64) of the NCI‐H460 cell line in the ENCODE database, were marked with filled circles (●)