Table 3. Fitted parameters for the MWC-type models.
, and their associated quantiles are reported as values.
| Full MWC | ||||
|---|---|---|---|---|
| Construct | Term | Estimate | 2.5% Quantile | 97.5% Quantile |
| Kir6.2*-GFP + SUR1 | −1.05 | −1.85 | −0.45 | |
| n = 9 | 0.04 | 0.00 | 0.19 | |
| 4.32 | 4.21 | 4.44 | ||
| Kir6.2*,C166S-GFP + SUR1 | 0.29 | −1.04 | 1.41 | |
| n = 6 | 0.84 | 0.52 | 0.95 | |
| 4.18 | 3.93 | 4.47 | ||
| Kir6.2*-GFP + SUR-K205A | −0.37 | −1.34 | 0.41 | |
| n = 9 | 0.55 | 0.39 | 0.65 | |
| 3.76 | 3.59 | 3.95 | ||
| Kir6.2*-GFP + SUR-K205E | −0.18 | −1.25 | 0.70 | |
| n = 9 | 0.62 | 0.42 | 0.74 | |
| 3.40 | 3.21 | 3.62 | ||
| Single-site | ||||
| Kir6.2*-GFP + SUR1 | −1.06 | −1.84 | −0.47 | |
| n = 9 | 0.05 | 0.01 | 0.10 | |
| 4.33 | 4.22 | 4.44 | ||
| Kir6.2*,C166S-GFP + SUR1 | 0.09 | −1.15 | 1.05 | |
| n = 6 | 0.70 | 0.29 | 0.91 | |
| 4.15 | 3.88 | 4.43 | ||
| Kir6.2*-GFP + SUR-K205A | −0.25 | −1.30 | 0.53 | |
| n = 9 | 0.18 | 0.06 | 0.32 | |
| 3.62 | 3.45 | 3.83 | ||
| Kir6.2*-GFP + SUR-K205E | −0.19 | −1.19 | 0.52 | |
| n = 9 | 0.30 | 0.13 | 0.47 | |
| 3.31 | 3.13 | 3.50 | ||
| Negative cooperativity | ||||
| Kir6.2*-GFP + SUR1 | −0.42 | −1.38 | 0.48 | |
| n = 9 | 0.15 | 0.02 | 0.29 | |
| 4.82 | 4.54 | 5.29 | ||
| 0.17 | 0.06 | 0.36 | ||
| Kir6.2*,C166S-GFP + SUR1 | 0.32 | −0.96 | 1.47 | |
| n = 6 | 0.83 | 0.50 | 0.94 | |
| 4.43 | 4.04 | 5.14 | ||
| 0.52 | 0.09 | 0.97 | ||
| Kir6.2*-GFP + SUR-K205A | −0.16 | −1.18 | 0.64 | |
| n = 9 | 0.52 | 0.32 | 0.64 | |
| 4.10 | 3.73 | 4.68 | ||
| 0.35 | 0.10 | 0.91 | ||
| Kir6.2*-GFP + SUR-K205E | −1.11 | 0.99 | ||
| n = 9 | 0.58 | 0.32 | 0.73 | |
| 3.71 | 3.34 | 4.41 | ||
| 0.45 | 0.10 | 0.96 |