Figure 1. Subacute treatment with irisin promotes dendritic enlargement of hippocampus through enhancing hippocampal transcripts of pgc-1a, fndc5, bdnf, and hevin, but reducing tgf-b1.

A. Experimental design. Mice were intraperitoneally injected with irisin for seven days, followed by the sacrifice two days later. B-D. Quantitative analysis of dendritic length, branch point, and spine numbers. E. Quantitative analysis of pgc-1a, fndc5, bdnf mRNA. F. Quantitative analysis of tsp-1, tsp-2, hevin, sparc, tgf-b1.

Data are presented as the mean ± standard error of the mean. *p < 0.05, **p < 0.01.