Table 3. Functional characteristics of common liver cell models.
| Basal OCR [nmol/(min·106 cells)]b | BFC clearance rate [pmol/(min·mg protein)] | Albumin synthesis rate [μg/(day·106 cells)] | |
|---|---|---|---|
| HepG2/C3A | 2 | 0.2 | 2 |
| hPSC-derived hepatocytesa | 4.5 | 3 | 12 |
| HepaRG | 5 | 7 | 10 |
| E6/E7low Upcyte hepatocytes | 8 | 6.24 | 7 |
| Primary hepatocytes | 24 | 12 | 25 |
a
hPSCs include embryonic and induced cells.
b
Measured on a SeaHorse FluxAnalyzer.
Abbreviations: BFC, 7-benzyloxy-4-trifluoromethylcoumarin; hPSC, human pluripotent stem cell; OCR, oxygen consumption rate.