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. Author manuscript; available in PMC: 2020 Feb 6.
Published in final edited form as: Vaccine. 2018 Mar 22;36(17):2254–2261. doi: 10.1016/j.vaccine.2018.02.049

Table 1. Number of systematic reviews by disease/pathogen.

Disease/pathogen specific estimates

Disease/pathogen area Quantity % of total
Influenza 260 20%
Human papillomavirus 173 13%
Pneumococcus 145 11%
Hepatitis B 96 7%
Rotavirus 54 4%
Measles 50 4%
Pertussis 49 4%
Tetanus toxoid 41 3%
Varicella 37 3%
Tuberculosis 35 3%
Rubella 33 3%
Haemophilus influenzae type b (Hib) 32 2%
Poliomyelitis 29 2%
Herpes zoster 26 2%
Diptheria 25 2%
Mumps 23 2%
Combination vaccine 19 1%
Hepatitis A 18 1%
Meningococcal infection 16 1%
Cholera 11 1%
Yellow fever 10 1%
Dengue 8 1%
Malaria, Rabies 7 1%
Smallpox 6 <1%
Escherichia coli, HIV (each) 5 <1%
Japanese encephalitis 4 <1%
Hepatitis C, Leishmaniasis, Salmonella (each) 3 <1%
Adenovirus, Anthrax, Coxiella burnetii (Q fever), Ebola, Shigella, Tick-borne encephalitis, Typhoid (each) 2 <1%
Campylobacter, Enterovirus vaccine (hand foot and mouth), Herpes simplex, Mycobacterium leprae, Mycobacterium vaccae, Pseudomonas aeruginosa, Respiratory Syncytial Virus (RSV), Streptococcus group B (each) 1 <1%
Summary estimates
All systematic reviews 1285 100%
On general vaccination/immunization topic 312 24%
On disease-specific topic 973 76%
On one disease/pathogen area 859 67%
On two or more disease/pathogen area 114 9%