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. Author manuscript; available in PMC: 2021 Feb 4.
Published in final edited form as: Structure. 2019 Dec 3;28(2):223–235.e2. doi: 10.1016/j.str.2019.11.007

Figure 3.

Figure 3.

Druggability scores (DSs) of unliganded structures of proteins with DS distributions skewed toward the unbound state. The distributions of DS values are shown in dark, light, and medium blue, respectively, for unbound structures, complexes, and mutants. The label shows the 3-letter code of the ligand bound at the cryptic site, and the name of the ligand is shown in parenthesis here. A. Pyruvate kinase (ATP plus oxalate). B. Ricin (pteroic acid). C. Ribonuclease A (NADPH). D. Hepatitis C virus RNA polymerase NS5B (indole-based allosteric inhibitor binding at the thumb domain). E. Protein tyrosine phosphatase 1B (allosteric inhibitor binding at the C-end). F. Fructose-1,6-bisphosphate aldolase enzyme from rabbit muscle (naphthol AS-E phosphate, a competitive inhibitor.).