Table 1.

Proteins with cryptic sides studied

Apoa	Holoa	Ligb	Name	Nc	Figure	Site
2CM2_A	2H4K_A	509	PTP1B	19	1	High affinity pTyr binding site
1 PKL_B	3HQP_P	ATP	Pyruvate kinase enzyme	10	3A	ATP+Oxalate binding site
1RTC_A	1BR6_A	PT1	Ricin	23	3B	Pteroic acid binding at the active site
1RHB_A	2W5K_B	NDP	Ribonuclease A.	83	3C	NADPH binding at the active site
3CJ0_A	2BRL_A	POO	HCV polymerase NS5B	249	3D	Between fingers and thumb domains
2F6V_A	1T49_A	892	PTP1B	108	3E	Allosteric site under the C-terminal helix
1ZAH_B	2OT1_D	N3P	Fructose aldolase	36	3F	Competitive inhibitor binding site
1 G24_D	1GZF_C	NIR	Rho ADP-Ribosyl. Enz.	15	S1	Structure also contain NAD and ADP
1 W50_A	3IXJ_C	586	BACE-1 protease	19	4	Active site, too open in apo structure
1BSQ_A	1 GX8_A	RTL	Bovine Beta-lactoglobulin	34	5A	Retinol binding in the central cavity
1HAG_E	1GHY_H	121	Thrombin	52	5B	Pocket is too open with flexible loops
3F74_C	3BQM_C	BQM	Alpha-L (Integrin) domain	25	5C	Active site with disordered C terminus
1MY0_B	1N0T_D	AT1	Glutamate receptor 2	26	5D	Stabilizes the open form of the receptor
1XCG_B	10W3_B	GDP	Transforming protein	12	S2	GDP interacts only with RhoA
1 JWP_A	1 PZ0_A	CBT	TEM β-lactamase	21	6	Allosteric site between two helixes
2BLS_B	3GQZ_A	GF7	AMPc beta-lactamase	35	8A	Weak peripheral allosteric site
2BU8_A	2BU2_A	TF1	Pyruvate dehyd. kinase	11	8B	Allosteric inhibitor site
3CJ0_A	3FQK_B	79Z	HCV polymerase NS5B	143	8C	Binding near the active site.
2BRK_A	2GIR_B	NN3	HCV polymerase NS5B	186	S3A	Non-nucleotide inhibitor (thumb) site
1FXX_A	3HL8_A	BBP	Exodeoxyribonuclease I	14	8D	BBP prevents Exol/SSB interactions
1OK8_A	10KE_B	BOG	Dengue 2 virus envelope	15	8E	Site is between two domains
2AKA_A	1 YV3_A	BIT	Myosin II	30	8F	Narrow planar ligand binding site
3MN9_A	3EKS_A	CY9	Monomer. actin with toxin	36	S3B	Binding to the barbed end of filaments
1 NUW_A	1 EYJ_B	AMP	Fruct. 1,6- bisphosphatase	25	S3C	AMP binding site
3PUW_E	1FQC_A	GLO	Maltodextrin/maltose BP	19	S3D	Interdomain binding
3KQA_B	3LTH_A	UD1	MurA dead-end complex	13	S3E	Interdomain binding
3GXD_B	2WCG_A	MT5	Acid-beta-glucosidase	26	S3F	Active site
1BNC_B	2V5A_A	LZL	Biotin carboxylase	18	S4A	ATP competitive inhibitor site
1MY1_C	1FTL_A	DNQ	Glutamate receptor 2.	26	S4B	Interdomain binding
2AX9_A	2PIQ_A	RB1	Androgen receptor	23	S4C	Allosteric inhibitor binds on surface
2ZB1_A	2NPQ_A	BOG	P38 MAP kinase	144	S4D	Helix 253–261 moves outward
2AIR_H	1ZA1_D	CTP	Aspartate transcarbamylase	60	S5	Binds CTP at the flexible N-terminal

^aPDB ID of the apo and holo structures in the CryptoSite database.

^bName of the ligand binding at the cryptic site.

^cNumber of structures considered.