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Schematic showing PLT-mediated mechanisms of hemostasis and the design of artificial PLTs inspired by them; for example, SynthoPlate is a bioinspired “artificial PLT” design using a liposomal template that recapitulates the hemostatically relevant adhesion and aggregation mechanisms of PLTs and can further allow targeted exposure of procoagulant lipids (e.g., phosphatidylserine [PS]) as well as delivery of adjunctive therapeutic molecules to further augment hemostatic outputs.
