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. Author manuscript; available in PMC: 2021 Feb 4.
Published in final edited form as: Cell Metab. 2019 Dec 5;31(2):339–350.e4. doi: 10.1016/j.cmet.2019.11.012

Figure 2: Acute activation of Nrf2 induces dependency on NEAAs.

Figure 2:

a) Proliferation of wildtype (KrasG12D/+; p53−/−) murine LUAD tumor cell lines in the absence of serine or asparagine. b) Proliferation of Keap1 wildtype LKR (KrasG12D/+;p53+/+) cell lines in media lacking serine or asparagine. c) Proliferation of wildtype murine KrasG12D/+;p53−/− pancreatic cancer cell line in media lacking serine. d) Relative viability of Keap1 wildtype murine KrasG12D/+;p53−/− pancreatic cancer cell line treated with L-asparaginase. e) Schematic depicting mechanism of action of oxidants used to activate Nrf2. f) Proliferation of wildtype cells in media lacking serine or asparagine after oxidant treatment. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.