FIGURE 3.

Geometric mean observed and model-predicted fraction of dose for [¹³C₁₀]retinol in plasma versus time for Bangladeshi, Guatemalan, and Filipino children. Symbols are observed data and lines are model simulations using the partially parallel model (see Results). For the Bangladeshi group, the super-child data set included 5–6 children/time except at 4 d when there were 40 children; for the Filipino group, there were 9–13 children/time and 112 at 4 d; the Guatemalan group included 8–16 children/time and 135 at 4 d. Mean data for the 3 groups were fit with use of a partially parallel modeling approach (see Methods for details); the model is shown in Figure 1. The model-calculated weighted sums of squares for plasma were 2.4E-07, 4.8E-08, and 8.8E-08 for the Bangladeshi, Filipino, and Guatemalan groups, respectively.