Figure 1.

Anatomic and metabolic tumor volumes (MTV) before and after chemoradiation in relation to recurrence. Patient 01 had a subtotal resection with residual MTV extending anteromedially beyond the surgical cavity, with a complete metabolic response 3 months post chemoradiation. He experienced delayed progressed at 19 months. Patient 02 underwent subtotal resection and demonstrated residual MTV along the medial cavity that persisted 3 months post-chemoradiation, with subsequent early recurrence at 9 months. Patient 03 underwent gross total resection, yet had residual MTV that reduced in volume at 3 months. He experienced distant recurrence remote from the original resection bed and MTV at 18 months. Red = enhancing gross tumor volume and surgical cavity (GTV-Gd); blue = MTV pre-CRT; cyan = MTV at 3 months; green = 95% isodose surface; purple = enhancing tumor recurrence volume.