Table 4.
Multivariate Cox proportional hazards model of progression free survival and overall survival
| OS∗ |
PFS∗ |
|||||
|---|---|---|---|---|---|---|
| Covariates† | HR | 95% CI | P value‡ | HR | 95% CI | P value‡ |
| KPS (vs KPS ≥90) | 15.6 | 4.0-62.5 | .000 | 6.0 | 1.5-23.8 | .01 |
| Age | 1.5 | 1.0-2.2 | .05 | 1.0 | 0.7-1.4 | .88 |
| STR (vs GTR) | 1.2 | 0.5-2.6 | .73 | 1.6 | 0.7-3.4 | .26 |
| Biopsy (vs GTR) | 3.3 | 1.2-9.3 | .03 | 5.1 | 1.7-15.3 | .004 |
| Gd-enhancing GTV | 1.3 | 0.8-2.0 | .91 | 1.2 | 0.8-2.1 | .45 |
| FLAIR-GTV | 1.0 | 0.7-1.5 | .98 | 1.3 | 0.9-2.0 | .28 |
| MTV pre-CRT | 1.2 | 0.7-2.2 | .91 | 1.6 | 0.8-3.0 | .28 |
| Baseline enhancing MTV | 1.4 | 0.8-2.5 | .91 | 1.4 | 0.8-2.5 | .29 |
| Baseline nonenhancing MTV | 0.9 | 0.6-1.4 | .91 | 1.0 | 0.7-1.5 | .98 |
| Baseline MTV outside FLAIR | 1.1 | 0.6-1.8 | .95 | 0.7 | 0.4-1.2 | .28 |
| Baseline MTV outside 95% IDS | 1.0 | 0.7-1.4 | .95 | 1.4 | 0.9-2.0 | .26 |
| Baseline MTV inside 95% IDS | 1.2 | 0.7-2.3 | .91 | 1.5 | 0.8-2.9 | .29 |
| MTV 3 month | 1.3 | 0.8-2.4 | .91 | 2.4 | 1.4-4.3 | .03 |
| Persistent MET-PET subvolume | 1.3 | 0.7-2.4 | .91 | 2.0 | 1.2-3.4 | .06 |
| Change in MTV from baseline | 1.1 | 0.7-1.7 | .95 | 1.8 | 1.1-3.1 | .09 |
Abbreviations: CI = confidence interval; FLAIR = Fluid attenuated inversion recovery; Gd = gadolinium; GTR = gross total resection; GTV = gross tumor volume; HR = hazard ratio; IDS = isodose surface; KPS = Karnofsky Performance Status; MGMT = O6-methylguanine-DNA methyltransferase; MTV = metabolic tumor volume; OS = overall survival; RT = radiation therapy; STR = subtotal resection.
11 models included with 4 covariates per model (age, KPS, extent of resection and imaging variable).
For continuous covariates, HR is per 1 SD.
For multiple testing, Benjamini-Hochberg method was used for false discovery rate (FDR) control with the FDR control rate set to 10%.