Table 2.
Characteristics of the naturally occurring genomic rearrangements in the PPRs of seven HEV genotype 3 strains.
| HEV strain | HEV subtype | Nature of insertion | Number of variants | Name of the recombinant variant | Position in PPR (nt) | Nature of the inserted fragment | Percent of quasi species |
|---|---|---|---|---|---|---|---|
| 6 | 3h | Human insert | 1 | Hepac-6 | 84–239 | Ring finger protein 19A (RNF 19A) | 100% |
| 26 | 3chi-new | Human insert | 2* | Hepac-26-2 | 81–230 | Human ribosomal protein L6 (RPL6) | 21% |
| 94 | 3f | Human insert | 2* | Hepac-94-2 | 57–164 | Ribosomal protein 17S (RPS17) | 63% |
| 93 | 3f | Human insert | 3* | Hepac-93-2 | 166–222 | Eukaryotic translation elongation factor 1 alpha 1 pseudogene 13 (EEF1A1P13) | 12% |
| Hepac-93-3 | 164–242 | 18S ribosomal pseudogene 5 (RNA18SP5) | 31% | ||||
| 154 | 3f | Human insert | 1 | Hepac-154 | 170–247 | Kinesin family member 1B (KIF1B) | 100% |
| 64 | 3f | Human insert | 1 | Hepac-64 | 181–318 | Zinc finger protein 787 (ZNF787) | 100% |
| 12 | 3e | HEV duplication | 3 | Hepac-12-1 | 93–239 | PPR + X-domain | 67% |
| Hepac-12-2 | 85–237 | PPR | 22% | ||||
| Hepac-12-3 | 84–239 | PPR | 11% |
*
Strains with one wild type variant.