TABLE 1.
Processes involving dynein in C. elegans one-cell embryos.
Processes (*1) | Localization of dynein in action | Other subunit involved | Accessory proteins involved | References |
Oocyte meiotic spindle formation | Gonczy et al., 1999 | |||
Attachment of the centrosomes to the sperm pronucleus | Nuclear surface | ZYG-12, SUN-1 | Gonczy et al., 1999; Malone et al., 2003 | |
Centrosome separation | Nuclear surface, Cell cortex | ZYG-12, SUN-1, GPA-16, GOA-1 | Gonczy et al., 1999; Malone et al., 2003; De Simone et al., 2018 | |
Oocyte pronuclear migration | Nuclear surface | DNC-1, DNC-2 | ZYG-12, SUN-1 | Skop and White, 1998; Gonczy et al., 1999 |
Sperm pronuclear migration and centering | Cytoplasm, Cell cortex (*2) | DNC-1, DNC-2, DYRB-1 LIS-1/NudE | ZYG-12, SUN-1, RILP-1 | Skop and White, 1998; Gonczy et al., 1999; Cockell et al., 2004; Kimura and Onami, 2005; Goulding et al., 2007; Kimura and Kimura, 2011 |
Nuclear rotation | Cell cortex, Cytoplasm | DNC-1, DNC-2 | Skop and White, 1998; Gonczy et al., 1999; Kimura and Onami, 2007 | |
Mitotic spindle formation | LIS-1/NudE | SPDL-1, Rod/Zwilch/Zw10 | Gassmann et al., 2008; Simoes et al., 2018 | |
Spindle displacement | Cell cortex | DYRB-1 | PAR-2, PAR-3, GPA-16, GOA-1, GPR-1, GPR-2, LIN-5 | Grill et al., 2001; Colombo et al., 2003; Couwenbergs et al., 2007; Nguyen-Ngoc et al., 2007; Fielmich et al., 2018 |
Spindle rocking | Cell cortex | GPA-16, GOA-1, GPR-1, GPR-2 | ||
Spindle elongation | Cell cortex | GPA-16, GOA-1, GPR-1, GPR-2 |
*1, In temporal order; *2, Antagonistic role, see text.