Fig. 4. ChromA annotations generalize to single-cell data sets.

a Annotations of mouse A20 single-cell data sets at the Stat3 genomic locus. Cells are downsampled from 10,000 to 500 cells. ChromA annotations are consistent at different cell depths. b–e ChromA extends its effective genome-wide performance to single-cell data sets, again, recalling the highest number of ChIP-seq calls in GM12878 single-cell data sets. ChromA is particularly effective at low cell depths. b The number of ChIP-seq peaks recalled, c the total number of peaks and (d) fraction of the genome annotated as accessible for each downsampled data set. e Correlation between annotations at different cell depths calculated against the entire data set possessing 10,000 cells.