Table 3.

Univariate and multivariate analysis of clinical and biological factors influencing PFS and OS of transplant-ineligible patients in our cohort.

Variable	Univariate analysis for PFS		Multivariate analysis for PFS		Univariate analysis for OS		Multivariate analysis for OS
	Median survival	p	HR [95% CI]	p	Median survival	p	HR [95% CI]	p
ECOG score
0−1	26.94	0.003		NS		NS
2−4	21.35
Serum hemoglobin
<9 g/dL	14.03	0.001		NS	24.54	0.002		NS
≥9 g/dL	28.32				64.85
Post induction response
sCR/CR	49.35	0.008	0.311 [0.196−0.494]	1E−05	Not reached	0.00026	0.347 [0.154−0.780]	0.010
VGPR/PR	23.88				53.19
Cytogenetic risk
High risk	36.30	0.196		NS	78.59	0.031	0.369 [0.164−0.832]	0.016
Standard risk	25.03				39.95
IGHD4 usage
Yes	14.49	0.036		NS		NS
No	27.96
IGHD4-11 usage
Yes	14.16	0.0003		NS		NS
No	26.94
IGHD2 and IGHD3 usage
Yes	34.46	0.012	0.552 [0.361−0.845]	0.006		NS
No	23.46
SHM level
<7%	23.46	0.006		NS	34.73	0.00024	0.291 [0.137−0.618]	0.001
≥7%	26.45				64.85

Univariate analysis was first performed to evaluate the role of each clinical and biological variable described in this study. The table only shows statistically significant variables that were later included in the multivariate analysis. Median survival is shown in months.

HR hazard ratio, CI confidence interval, NS nonsignificant.