Table 2.

(A) Global miRNA association study of late-life depression (N = 300) and (B) depression-associated miRNAs are associated with dementia features.

miRNA	Coefficient	Coefficient SE	p	Adjusted p	Direction
(A)
miR-484	−0.710	0.200	0.00038	0.04573	Lower miR-484 ~ greater depression
miR-26b-5p	−0.667	0.189	0.00042	0.04573	Lower miR-26b ~ greater depression
miR-197-3p	−0.540	0.154	0.00047	0.04573	Lower miR-197 ~ greater depression
miR-30d-5p	−0.919	0.270	0.00066	0.04841	Lower miR-30d ~ greater depression
Predictor	Coefficient	Coefficient SE	p	Outcome	Direction
(B)
Regression model for rate of cognitive decline adjusting for relevant covariatesa (N = 482)
miR-484	0.03	0.01	0.012	Cognitive decline	Lower miR-484 ~ faster decline
miR-197-3p	0.02	0.01	0.020	Cognitive decline	Lower miR-197 ~ faster decline
Regression model for clinical diagnosis of dementia adjusting for relevant covariatesa (N = 505)
miR-484	−0.15	0.06	0.009	Dementia	Lower miR-484 ~ dementia

(A) miRNAs significantly associated with late-life depression at FDR p < 0.05 from a global miRNA association study of longitudinally assessed depression, adjusting for sex; age at visit; global AD pathology; proportions of neurons, oligodendrocytes, astrocytes, and microglia; postmortem interval; RIN; and study. All miRNAs were downregulated in greater depression. (B) Depression-associated miRNAs are also associated with dementia features after adjusting for sex; age at death; PMI; RIN; proportions of neurons, oligodendrocytes, astrocytes, and microglia; postmortem interval; RIN; and study

^aAdjusted for sex, age at death, education, PMI, RIN, cell type, and study