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. 2020 Feb 6;11(2):98. doi: 10.1038/s41419-020-2288-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, b Blood vessels were stained by PECAM-1 and pericytes by PDGFRβ. Increased pericyte coverage and microvessel tortuosity (arrows and framed areas) is seen in P7 TgCRND8 cortex; scale bar 20 μm. (a′, b′) Enlarged white-framed areas in a and b showing samples of normal microvessels in WT (a′) and tortuous microvessels (*) in TgCRND8 (b′) cortex; scale bar 10 μm. c There is increased PDGFRβ⁺ pericyte coverage in TgCRND8 cortex (*p < 0.05). d There is an increase in PECAM-1⁺ area in TgCRND8 cortex (*p < 0.05). e No difference in vessel diameter was detected (p > 0.05); mean ± SD (n = 2 (WT), n = 4 (TgCRND8), Student’s t-test.