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. 2020 Feb 6;11(2):98. doi: 10.1038/s41419-020-2288-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Schematic diagram of our working hypothesis for increased sprouting angiogenesis in TgCRND8 (b) compared to WT (a) tissue. Increased APP processing by BACE1 in TgCRND8 OBSCs competes with NOTCH3 for γ -secretase or reduces γ-secretase activity, thereby lowering transcriptional signalling through NICD. This reduces Notch3-Jag1 expression via autoregulatory mechanisms, thereby releasing the inhibitory influence on sprouting angiogenesis. Created with BioRender.