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. 2020 Feb 6;10:2030. doi: 10.1038/s41598-020-58922-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Variation of viscosity with time for healthy, COPD and NMD models during the cough process (relative mucus viscosity = mucus viscosity/water viscosity (0.001 pa·s, 20 °C)). The curves for healthy, COPD and NMD models are marked red, blue and green, respectively. For the healthy model, the viscosity decreases to the same level as that of water because of the high airflow produced in cough behavior.