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. 2020 Jan 31;7:4. doi: 10.3389/fmolb.2020.00004

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Copyright © 2020 Bagherpoor Helabad, Volkenandt and Imhof.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagram of protein-DNA hydrogen-bond interactions for (left) AR-DR and (right) GR-IR. The nucleotides of the 15 bps core DNA sequence are numbered from HS1 (numbers: 1–6) to HS2 (numbers: 10–15). The spacer region is highlighted with non-colored boxes around the numbers of the bases (numbers: 7–9). The hydrogen bonds are categorized based on their occupancy, 50–75% (gray), and 75–100% (black). The water mediated hydrogen bonds are shown with a blue letter “W.” The residues shown with star sign form base-specific hydrogen-bond interactions while the other residues interact with the backbone of the DNA.